Research Articles
Striking the Balance: Strategies for Managing Model Realism and Computational Feasibility in Drug Development
This article addresses the central challenge of balancing high-fidelity model realism with computational feasibility in drug discovery and development.
Advanced Threshold Selection for Asymmetry Graph Analysis: Methodologies, Optimization, and Applications in Biomedical Research
This article provides a comprehensive guide to threshold selection in asymmetry graph analysis, a critical technique for modeling complex, non-symmetric relationships in biomedical data.
Reconciling Food Web Models: From Ecological Theory to Biomedical Application
This article addresses the pervasive challenge of conflicting results generated by quantitative food web models, a critical issue for researchers in ecology and biomedical fields like drug development, where predictive...
Balancing Act: Optimizing Model Complexity for Accurate Food Web Projections in Ecological Research
This article synthesizes current research to provide a comprehensive framework for optimizing model complexity in food web projections.
Bridging the Gap: Advanced Methods for Integrating Social-Ecological Systems into Food Web Models
This article addresses the critical challenge of integrating social and ecological dimensions within food web modeling to enhance predictive accuracy and policy relevance.
Navigating Critical Species Interactions: A Sensitivity Analysis Framework for Precision Medicine and Drug Development
This article provides a comprehensive framework for applying sensitivity analysis to critical species interactions in biomedical research and drug development.
Navigating the Unknown: A Modern Framework for Addressing Structural Uncertainty in Food Web Models
Structural uncertainty—arising from incomplete knowledge of species interactions, network topology, and model architecture—represents a critical challenge in ecological forecasting and ecosystem-based management.
Ecosystem Traits Index (ETI): A Network-Based Framework for Marine Ecosystem-Based Management
This article introduces the Ecosystem Traits Index (ETI), a novel composite indicator developed to operationalize Ecosystem-Based Fisheries Management (EBFM).
Qualitative Network Analysis and Press Perturbations: A Framework for Predicting Systemic Responses in Complex Biological Networks
This article provides a comprehensive guide to Qualitative Network Analysis (QNA) for researchers and drug development professionals seeking to predict system-wide responses to sustained perturbations.
OSMOSE: A Comprehensive Guide to the Individual-Based Model for Marine Ecosystem Forecasting and Management
This article provides a comprehensive overview of the Object-oriented Simulator of Marine ecosystem Exploitation (OSMOSE), an individual-based, multispecies model crucial for ecosystem-based fisheries management (EBFM).